Foot-and-mouth disease virus (FMDV), family Picornaviridae, genus Aphthovirus causes an acute vesicular disease of pigs and wild and domesticated ruminants such as sheep, goats, cattle, water buffalo, and deer. It can cause high death rates in young animals and production losses in adults and is considered to be the single most important constraint to world trade in live animals and animal products. FMDV has a genome consisting of a single strand of positive-sense RNA and seven serotypes of FMDV exist: SAT 1, SAT 2, and SAT 3 are usually restricted to Africa; Asia 1 is restricted to Asia; and O, A, and C are present in Africa, Asia, and South America and occasionally Europe.
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