WIN Symposium 2025 Agenda – What’s On When

Location: Philadelphia Convention Center • Dates: Friday, October 3 – Saturday, October 4, 2025

Tracks & Rooms: Track 1 – Room 126  |  Track 2 – Room 120

Program Leadership

• Co-Chairs: Andrea Ferreira-Gonzalez; Wafik S. El-Deiry, MD, PhD, FACP (WIN Consortium; Legorreta Cancer Center, Brown University).
• WIN Symposium CMO: Razelle Kurzrock, MD (MCW Cancer Center; WIN Consortium).
• Multi-Omics Chair: Andrea Ferreira-Gonzalez • Session Chair: Arutha Kulasinghe, PhD (Queensland Spatial Biology Centre).

Day 1 — Friday, October 3, 2025

• 7:45–8:45 — Registration & Check-in (Philadelphia Convention Center)
• 8:40–9:00 — Welcome & Introduction
  Speakers include: Wafik S. El-Deiry, MD, PhD, FACP; Nigel Russell (Advancing Precision Medicine); Christopher P. Molineaux (Life Sciences PA).
• 9:00–9:40 — Keynote Lecture – WIN Consortium
  Targeting the Achilles’ Heel of Cancer: Synthetic Lethality and Hypoxia in Precision Oncology — William G. Kaelin, Jr., MD (2019 Nobel Laureate; Harvard/Dana-Farber).

SESSION 1 • From Base Pairs to Better Care: AI & Omics in Precision Oncology (Track 1 | 9:40–10:40)

• 9:40–10:00 — Multi-Omic Profiling & Clinical Decision Support — David Spetzler, PhD, MBA, MS (Caris Life Sciences)
• 10:00–10:20 — Integrating Omics & AI for Next-Gen Precision Oncology — Keith T. Flaherty, MD, FAACR (MGH/Harvard; AACR President-Elect 2025–2026)
• 10:20–10:40 — Real-World Data & AI: Making Data Work for Patients (Q&A) — Moderator: Jeff Elton, PhD (ConcertAI); Panelists: Spetzler; Flaherty

SESSION 1 • Multi-Omics Approaches in Precision Medicine (Track 2 | 9:40–10:50) — Chair: Arutha Kulasinghe, PhD

• 9:40–10:00 — Kurt A. Schalper, MD, PhD (Yale)
• 10:00–10:15 — Justin Davis, PhD (Ignite Proteomics)
• 10:15–10:30 — Hoifung Poon, PhD (Microsoft Research)
• 10:30–10:45 — Michael Smith, PhD (Illumina)
• 10:45–10:50 — Panel Discussion

10:40–11:10 — Break & Exhibits

SESSION 2 • The Evolution of Precision Oncology: Integrating MRD, AI, and Beyond (11:10–1:10)

• 11:10–12:00 — Precision Cancer Consortium (Gabriele Allegri; Shruti Mathur; Daryl Pritchard; Keith T. Flaherty)

SESSION 3 • The Shifting Landscape: Tumor Plasticity & Resistance (12:00–1:00)

• 12:00–12:20 — Mathematical/Evolutionary Modeling in Precision Radiation Oncology — Jacob Scott, MD, DPhil (Cleveland Clinic)
• 12:20–12:40 — EMT in Cancer Progression & Therapy Resistance — Sendurai A. Mani, PhD (Brown/Legorreta)
• 12:40–1:00 — Targeting Molecularly Defined Subsets — Benedito A. Carneiro, MD, MS (Brown/Legorreta)

Spatial-Omics Applications (Track 2 | 11:15–12:30) — Chair: Arutha Kulasinghe, PhD

• Sizun Jiang, PhD • Jiwoon Park, PhD • Michael Schnall-Levin, PhD • Abhishek Aggarwal, PhD
• 12:20–12:30 — Panel Discussion

12:30–1:00 — Non-CME Industry Perspectives: Illumina, 10x Genomics, Stellaromics

1:00–1:50 — Lunch & Exhibits

SESSION 4 • From Targets to Trials: Translating Discovery into Impact (1:50–4:05)

• 1:50–2:10 — Targeted Immunotherapeutics Beyond Checkpoints — Matthew Hadfield, DO (Brown)
• 2:10–2:30 — Molecular Profiling in Early-Phase Trials — Apostolia M. Tsimberidou, MD, PhD (MD Anderson)
• 2:30–2:40 — Q&A
• 2:40–3:20 — Non-CME: Venture Philanthropy — Eric Heil, MBA (Medical Excellence Capital); John Lehr (Parkinson’s Foundation); Blaine Robinson, PhD (Blood Cancer United)
• 3:20–4:10 — eNSCLC Testing — Kurt A. Schalper, MD, PhD (Yale)

Parallel Sessions (Track 2)

• 1:50–2:35 — Non-CME AI & Digital Pathology — Shruti Mathur, MS; Kimbery Gasaud, MBA; Paul J. Beresford, PhD; Keith Wharton
• 2:35–3:50 — Omics Into the Clinic — Chair: Sizun Jiang, PhD; Talks by Arutha Kulasinghe, PhD; Thazin Nwe Aung, MD; Clemens Duerrschmidt, PhD (Quanterix); Panel with Laura Dillon, PhD; Jared K. Burks, PhD; Hoifung Poon, PhD

4:10–4:25 — Break & Exhibits

Late-Day Sessions (4:25–6:45)

• 4:25–5:15 — Transforming Pediatric Oncology: The Power of Precision Medicine — Giselle L. Sholler, MD; Wei Zhang, PhD; Elias Sayour, MD, PhD; Milan Radovich, PhD; Pei Wang, PhD; Abigail Moore
• 5:15–5:25 — Informing Therapy Decisions for Improved Patient Care — Ashley Varghese, PharmD, RPh
• 5:25–5:50 — Liquid Biopsies & Resistance Monitoring — Pashtoon Kasi, MD, MS (City of Hope)
• 5:50–6:10 — Liquid Biopsies in Clinical Practice — Hatim Husain, MD (UC San Diego)

Parallel: Multi-Omics (Track 2 | 4:20–5:30) — Chair: Jiwoon Park, PhD

• Jared K. Burks, PhD (MD Anderson) • Aruna Ayer, PhD (BD Biosciences) • Harsha Gowda, PhD (Signios Bio)
• 5:10–5:30 — Panel Discussion
• 5:30–6:00 — Non-CME Industry Perspectives: Vizgen, Stellaromics, Signios Bio

6:15–7:15 — Networking Reception

Day 2 — Saturday, October 4, 2025

• 7:45–8:30 — Registration & Check-in
• 8:30–8:35 — Welcome • Introductions • Day 1 Recap
• 8:35–8:55 — Keynote Lecture: Collaborating for Patient Access or Reinforce Inequality? — Gabriele Allegri, MBA (J&J Innovative Medicine)

SESSION 1 • Precision For All: Global Access, Real Cases & Implementation Science (8:55–10:35)

• 8:55–9:15 — Results & Future Direction from WIN’s Data Science Paper — Gerald Batist, MD (McGill)
• 9:15–9:55 — WIN International Molecular Tumor Board (Live) — Wafik S. El-Deiry, MD, PhD, FACP; Razelle Kurzrock, MD

SESSION 2 • Expanding the Precision Frontier (9:55–10:35)

• 9:55–10:25 — Immunotherapy Era: Biomarkers & Trial Innovation — Lillian Siu, MD (Princess Margaret Cancer Centre)
• 10:25–10:35 — Microbiome in Cancer Development & Treatment Response — Sabine Hazan, MD

Parallel: Precision Therapy for Rare Disease (Track 2 | 9:00–11:00)

Speakers include: Marni Falk, MD (CHOP); Sundeep Dugar, PhD (Aayam Therapeutics); Chris Jeffers (BioAdvisory); Howard McLeod, PharmD (Utah Tech); Mimi Lee, MD, PhD (ARPA-H); Niven R. Narain, PhD (BPGbio); Chris Marsh (UBS).

10:35–11:00 — Networking, Exhibits & Product Presentations

SESSION 3 • Advances in Precision Oncology: From Genomics to Targeted Therapies (11:00–1:05)

• 11:10–11:55 — Targeting KRAS in Pancreatic Cancer — Michael Pishvaian, MD (Johns Hopkins); Kim Reiss, MD (University of Pennsylvania)
• 11:55–12:15 — Precision Oncology & the Power of Genomics — Vivek Subbiah, MD (Sarah Cannon)
• 12:15–12:35 — Molecular Pathology in Urological Cancers — Liang Cheng, MD (Brown/Lifespan)
• 12:35–12:55 — Epigenetic Plasticity & Tumor Evolution — Johnathan R. Whetstine, PhD (Fox Chase Cancer Center)
• 12:55–1:05 — Panel Q&A (Subbiah; Cheng; Whetstine)

Parallel: Companion Diagnostics — Non-CME (11:30–12:30)

• Huw Ricketts, PhD (QIAGEN); Tricia Carrigan, PhD (BC Biosolutions); Arushi Agarwal, MS (Health Advances); Melissa Reuter, MS, MBA (GSK)

12:30–12:40 — Non-CME — dSTRIDE™-HR: Functional Biomarker for in situ, real-time HR Activity — Magda Kordon-Kiszala, PhD (intoDNA)

1:05–2:00 — Lunch & Exhibits

SESSION 4 • Precision Without Borders: From Trial Evolution to Global Impact (2:00–3:30)

• 2:00–2:20 — Building Precision Oncology Infrastructure in LMICs — Sewanti Limaye, MD
• 2:20–2:40 — Co-targeting KIT/PDGFRA & Genomic Integrity in GIST — Lori Rink, PhD
• 2:40–3:00 — Abstract Presentations
• 3:00–3:30 — WIN Consortium Update 2025 — Wafik S. El-Deiry, MD, PhD, FACP; Razelle Kurzrock, MD

AI in Precision Medicine (1:40–2:30)

• Dr. Ganhui Lan (Genentech) • Dr. Xiaoyan Wang (Tulane/IMO) • Dr. Ahmad P. Tafti (University of Pittsburgh) • Moderator: Jen Gilburg (Commonwealth of Pennsylvania)

Tracks/rooms subject to change. Final timings will be confirmed on site.