Rickettsia bacteria are a pathogen transmitted to humans by Rhipicephalus ticks. Rickettsia conorii are known as a cause of “Mediterranean spotted fever, Astrakhan fever, Israeli spotted fever, and Indian tick typhus in the Mediterranean basin and Africa, Southern Russia, Middle East, and India, respectively. Rickettsia conorii is a Gram-negative, obligate intracellular bacterium of the genus Rickettsia. Rickettsiae enter into non-phagocytic host cells and adhere to it’s vacuole. Within the cytoplasm, rickettsiae begin to divide and are able to polymerize host actin filaments to drive themselves to be linked intra- and intercellularly. Rickettsia felis is a Gram-negative species of bacterium that causes cat-flea typhus in humans. In cats the disease is known as flea-borne spotted fever. Rickettsia felis also is regarded as the causative organism of many cases of illnesses generally classed as fevers of unknown origin in humans in Africa.