The Human herpes virus-3 (HHV-3) -family of herpesviruses- is the cause of chickenpox (varicella), and shingles (Herpes zoster). Varicella occurs as the primary infection, more commonly in childhood but can occur in adulthood. Herpes zoster is a result of reactivation of latent infection of nerve ganglia. Symptoms include fever, general malaise, abdominal pain, headache, followed by skin lesions; a rash which eventually crust and heal. The main route of HHV-3 infection is airborne transmission. In addition, direct contact may also transmit the virus.