Viral nervous necrosis is a disease found world-wide in many species of marine fish, causing an extremely high mortality of affected larvae and juveniles The agent of VNN has been identified as a new member of the Nodaviridae. Fish nodaviruses have been classified into four genotypes: tiger puffer nervous necrosis virus, striped jack nervous necrosis virus, barfin flounder nervous necrosis virus and red-spotted grouper nervous necrosis virus. Nerve tissue is the target tissue for nervous necrosis virus (NNV) infection, but NNV can also infect other tissues. The distribution of NNV in other tissues varies with fish species and age.
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